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Similarly, sesamol and sesaminol have shown neuroprotective effects in related models, often attributed to their ability to cross the bloodbrain barrier and act as free radical scavengers in the brain (68)

Research Notes Animal models demonstrate accelerated wound closure, enhanced collagen deposition, and improved muscle and nerve regeneration

Sustained benefits suggest successful healing

Its short half-life of approximately 30 minutes produces discrete, physiological GH pulses rather than the sustained tonic elevation associated with DAC-bound variants

The 13-amino-acid N-terminal extension (sequence MFPAMPLLSLFVN) shifts the three-dimensional conformation of the binding interface, while the Arg 3 Glu 3 substitution disrupts a key contact residue with IGFBPs